Antiviral actions of flavanoid-derived compounds on dengue virus type-2
Dengue viruses, mosquito-borne members of the Flaviviridae family, are the causative agents of dengue fever and its associated complications, dengue haemorrhagic fever and dengue shock syndrome. To...
View ArticleSurvival of Escherichia coli under lethal heat stress by L-form conversion
Transition of bacteria to cell wall deficient L-forms in response to stress factors has been assumed as a potential mechanism for survival of microbes under unfavorable conditions. In this article, we...
View ArticleCloning, characterization, and expression analysis of goat (Capra hircus)...
Phospholipid hydroperoxide glutathione peroxidase (PHGPx), as a ubiquitous antioxidant enzyme in the glutathione peroxidases (GPx) family, plays multiple roles in organisms. However, there is very...
View ArticleGeneration of Fgfr3 Conditional Knockout Mice
Fibroblast growth factor receptor 3 (FGFR3), highly conserved in both humans and murine, is one of key tyrosine kinase receptors for FGF. FGFR3 is expressed in different tissues, including cartilage,...
View ArticleWater Buffalo Genome Science Comes of Age
The water buffalo is vital to the lives of small farmers and to the economy of many countries worldwide. Not only are they draught animals, but they are also a source of meat, horns, skin and...
View ArticleDifferential transcriptional analysis between red and white skeletal muscle...
In order to better understand and elucidate the major determinants of red and white muscle phenotypic properties, the global gene expression profiling was performed in white (longissimus doris) and...
View ArticleRegulation of Vid-dependent degradation of FBPase by TCO89, a component of...
A pivotal gluconeogenic enzyme in Saccharomyces cerevisuae, fructose-1, 6-bisphosphatase (FBPase) was selectively turned over in vacuole via Vid (vacuole import and degradation) dependent pathway in...
View ArticleProliferation of Myoblast Skeletal Cells on Three-Dimensional...
Cardiac and skeletal muscle tissue engineering provides a smart approach to overcome problems associated with organ transplantation and cardiac tissue and also lays a platform for superior alternative...
View ArticleE2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity
E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation. Interaction between pRB and E2F-1 is dependent on the phosphorylation status of pRB. Despite the fact that...
View ArticleSustained Expression of TDP-43 and FUS in Motor Neurons in Rodent's Lifetime
TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoproteins. Pathogenic mutations of the TDP-43 or the FUS gene are all linked to amyotrophic lateral...
View ArticleSubtle evolutionary changes in the distribution of N-glycosylation sequons in...
Many viruses are known to undergo rapid evolutionary changes under selective pressures. The HIV-1 envelope glycoprotein 120 (gp120) shows extreme selection for NXS/T sequons, the potential sites of...
View ArticleFluorouracil Selectively Enriches Stem-like Leukemic Cells in a Leukemic Cell...
Recent studies have reported that cancer stem cells (CSCs) could be isolated from solid cancer cell lines, in which the purity of CSCs was higher than that from tumor tissues. Separation of CSCs from...
View ArticleIncreased invasiveness and aggressiveness in breast epithelia with...
Our previous studies revealed that pregnancy associated breast cancer (PABC) had significantly reduced nuclear p63 expression in myoepithelia, while intense cytoplasmic p63 expression in associated...
View ArticleCatalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the...
To investigate the role and mechanism of catalpol in brain angiogenesis in a rat model of stroke, the effect of catalpol (5 mg/kg; i.p) or vehicle administered 24 hours after permanent middle cerebral...
View ArticleExpression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors
Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline. The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study...
View ArticleSkeletal Muscle Stem Cells from Animals I. Basic Cell Biology
Skeletal muscle stem cells from food-producing animals are of interest to agricultural life scientists seeking to develop a better understanding of the molecular regulation of lean tissue (skeletal...
View ArticleSmaller cardiac cell size and reduced extra-cellular collagen might be...
Purpose: To test the hypothesis that cardiac morphologic differences between Ames dwarf and wild-type littermates might correlate with the increased longevity observed in the Ames dwarf mice.Methods:...
View ArticleIdentification and Molecular Characterization of a New Member of the...
The peritrophic membrane (PM) plays an important role in protecting insects. The PM proteins are important to determinate the formation and function of the PM. A new PM protein, named Lsti99, was...
View ArticleIncreased Proliferation and Analysis of Differential Gene Expression in Human...
Multipotent mesenchymal stromal cells (MSCs) from Wharton's jelly (WJ) of umbilical cord bear higher proliferation rate and self-renewal capacity than adult tissue-derived MSCs and are a primitive...
View ArticleBP1, an Isoform of DLX4 Homeoprotein, Negatively Regulates BRCA1 in Sporadic...
Introduction: Several lines of evidence point to an important role for BP1, an isoform of DLX4 homeobox gene, in breast carcinogenesis and progression. BRCA1 is a well-known player in the etiology of...
View ArticleAlpha-Calcitonin Gene-Related Peptide Can Reverse The Catabolic Influence Of...
Background and purpose: A linkage between the neurotransmitter alpha-calcitonin gene-related peptide (alpha-CGRP) and particle-induced osteolysis has been shown previously. The suggested...
View ArticleCircling behavior developed in Dmp1 null mice is due to bone defects in the...
With age, there is a progressive loss of body balance function. Yet, the potential influence of osteoporosis on body balance is largely unknown. Dentin matrix protein 1 (DMP1) is highly expressed in...
View ArticleMyocardial deletion of Smad4 using a novel α skeletal muscle actin Cre...
SMAD4 acts as the converging point for TGFβ and BMP signaling in heart development. Here, we investigated the role of SMAD4 in heart development using a novel α skeletal muscle actin Cre recombinase...
View ArticleActivity and interactions of antibiotic and phytochemical combinations...
In this study the in vitro activities of seven antibiotics (ciprofloxacin, ceftazidime, tetracycline, trimethoprim, sulfamethoxazole, polymyxin B and piperacillin) and six phytochemicals...
View ArticleAnterior Visceral Endoderm SMAD4 Signaling Specifies Anterior Embryonic...
SMAD4 serves as a common mediator for signaling of TGF-β superfamily. Previous studies illustrated that SMAD4-null mice die at embryonic day 6.5 (E6.5) due to failure of mesoderm induction and...
View ArticleConstruction of cDNA library and preliminary analysis of expressed sequence...
In this study we successfully constructed a full-length cDNA library from Siberian tiger, Panthera tigris altaica, the most well-known wild Animal. Total RNA was extracted from cultured Siberian tiger...
View ArticleDebate on GMOs Health Risks after Statistical Findings in Regulatory Tests
We summarize the major points of international debate on health risk studies for the main commercialized edible GMOs. These GMOs are soy, maize and oilseed rape designed to contain new pesticide...
View ArticleAberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated...
SIRT1, an NAD-dependent histone/protein deacetylase, has classically been thought of as a nuclear protein. In this study, we demonstrate that SIRT1 is mainly localized in the nucleus of normal cells,...
View ArticleAntennal expression pattern of two olfactory receptors and an odorant binding...
Odor-detection in the malaria mosquito Anopheles gambiae involves large families of diverse proteins, including multiple odorant binding proteins (AgOBPs) and olfactory receptors (AgORs). The...
View ArticleGene Expression Profiling of Skeletal Muscle of Nursing Piglets
To gain insight into the regulation mechanism associated with the rapid gain in skeletal muscle during neonatal period, gene expression profiles of skeletal muscle of nursing pigs was investigated...
View ArticleComparative Analysis of Cytotoxic T Lymphocyte Response Induced by Dendritic...
The choice of the tumor antigen preparation used for dendritic cell (DC) loading is important for optimizing DC vaccines. In the present study, we compared DCs pulsed with hepatocellular carcinoma...
View ArticleMechanical Forces Used for Cell Fractionation Can Create Hybrid Membrane...
The ability to understand the inner works of the cell requires methods for separation of intracellular membrane-enclosed compartments. Disruption of the plasma membrane (PM) by mechanical forces to...
View ArticleNuclear factor-Y (NF-Y) regulates transcription of mouse Dmrt7 gene by...
Dmrt7, a member of the Dmrt family of genes, is required for spermatogenesis. However, promoter functions of the gene Dmrt7 remain unknown. We have cloned and characterized the proximal promoter...
View ArticleMechanism of Processive Movement of Monomeric and Dimeric Kinesin Molecules
Kinesin molecules are motor proteins capable of moving along microtubule by hydrolyzing ATP. They generally have several forms of construct. This review focuses on two of the most studied forms:...
View ArticleThe application of Toll like receptors for cancer therapy
Toll-like receptor (TLR) proteins play key roles in immune responses against infection. Using TLR proteins, host can recognize the conserved molecular structures found in pathogens called...
View ArticleLiver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver...
SIRT1, a homolog of yeast Sir2, is a type III NAD+ dependent histone and protein deacetylase. Previous studies of mice carrying liver specific deletion of exon 4 of the Sirt1 gene revealed opposite...
View ArticleLipid metabolism, adipocyte depot physiology and utilization of meat animals...
Meat animals are unique as experimental models for both lipid metabolism and adipocyte studies because of their direct economic value for animal production. This paper discusses the principles that...
View ArticleBone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells
Bone morphogenetic proteins (BMPs) - expressed in the developing retina - are known to be involved in the regulation of cell proliferation and apoptosis in several tumor entities. The objective of...
View ArticleRole of clusters in insulin-regulated GLUT4 trafficking in adipose cells: A...
Insulin stimulates glucose transport in muscle and adipose cells by stimulating translocation of glucose transporter 4 (GLUT4) to the plasma membrane. In a recent Cell Metabolism paper, Stenkula et...
View ArticleGEP, a Local Growth Factor, is Critical for Odontogenesis and Amelogenesis
Granulin epithelin precursor (GEP) is a new growth factor that functions in brain development, chondrogenesis, tissue regeneration, tumorigenesis, and inflammation. The goal of this study was to study...
View ArticleViral Oncogenes, Noncoding RNAs, and RNA Splicing in Human Tumor Viruses
Viral oncogenes are responsible for oncogenesis resulting from persistent virus infection. Although different human tumor viruses express different viral oncogenes and induce different tumors, their...
View ArticleNon-Homologous End Joining Plays a Key Role in Transgene Concatemer Formation...
This study focused on concatemer formation and integration pattern of transgenes in zebrafish embryos. A reporter plasmid based on enhanced green fluorescent protein (eGFP) driven by Cytomegalovirus...
View ArticleThe Glypican 3-Hosted Murine Mir717 Gene: Sequence Conservation, Seed Region...
Mir717 (mmu-mir-717) was first reported in mouse and resides in the intron 3 of glypican 3 (Gpc3) gene. Our present study revealed that this microRNA (miRNA) gene is conserved among 26 mammalian...
View ArticleModulation of Mitochondrial Permeability Transition Pore Affects Multidrug...
Multidrug resistance (MDR) is a critical problem in the chemotherapy of cancers. Human hepatocellular carcinoma (HCC) responds poorly to chemotherapy owing to its potent MDR. Chemotherapeutic drugs...
View ArticleS-Adenosylmethionine Inhibits the Growth of Cancer Cells by Reversing the...
A global DNA hypomethylation might activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-Adenosylmethionine (SAM) serves as a major methyl donor in biological...
View ArticleApplications of Patient-Specific Induced Pluripotent Stem Cells; Focused on...
The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive...
View ArticleSRp20 is a proto-oncogene critical for cell proliferation and tumor induction...
Tumor cells display a different profile of gene expression than their normal counterparts. Perturbations in the levels of cellular splicing factors can alter gene expression, potentially leading to...
View ArticleAnalysis of Microsatellite DNA Markers Reveals no Genetic Differentiation...
Pacific threadfin, Polydactylus sexfilis, is popular fish in recreational fishing, as well as aquaculture in Hawaii. Its natural population has been continuously declining in the past several decades....
View ArticleMicrobial and Bioconversion Production of D-xylitol and Its Detection and...
D-Xylitol is found in low content as a natural constituent of many fruits and vegetables. It is a five-carbon sugar polyol and has been used as a food additive and sweetening agent to replace sucrose,...
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