Smad4-mediated TGF-β signaling in tumorigenesis
Transforming growth factor-β (TGF-β) family members exert their function via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors, including the...
View ArticleAn Overview of Stress Response and Hypometabolic Strategies in Caenorhabditis...
Studies of the molecular mechanisms that are involved in stress responses (environmental or physiological) have long been used to make links to disease states in humans. The nematode model organism,...
View ArticleA manually curated network of the PML nuclear body interactome reveals an...
Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to...
View ArticleKeratin promoter based gene manipulation in the murine conducting airway
Systems capable of targeting genetic manipulations to keratin-positive airway basal cells are more poorly developed than systems targeting other airway epithelial cell populations and this has likely...
View ArticleCellular and molecular comparison of redifferentiation of intramuscular- and...
In the present study, mature adipocytes from pig-derived visceral and intramuscular adipose depots were isolated, purified, and allowed to undergo dedifferentiation and redifferentiation in vitro....
View ArticleComparative study of the binding pockets of mammalian proprotein convertases...
Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins. Seven mammalian subtilisin/Kex2p-like proprotein convertases...
View ArticleOverexpression of bacterial ethylene-forming enzyme gene in Trichoderma...
In order to efficiently utilize natural cellulose materials to produce ethylene, three expression vectors containing the ethylene-forming enzyme (efe) gene from Pseudomonas syringae pv. glycinea were...
View ArticleHigh prevalence of multiple paternity in the invasive crayfish species,...
Reproductive strategy is a central feature of the ecology of invasive species as it determines the potential for population increase and range expansion. The red swamp crayfish, Procambarus clarkii,...
View ArticleE2F-1 has dual roles depending on the cell cycle
The E2F family of transcription factors play a critical role in the control of cell proliferation. E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation....
View ArticleAberrant leukocyte infiltration: a direct trigger for breast tumor invasion...
Our previous studies revealed that leukocyte infiltration could trigger breast and prostate tumor invasion through physical disruption of tumor capsules. Our current study, involving multiple types of...
View ArticleDoes the difference between physically active and couch potato lie in the...
Obesity and other inactivity related diseases are increasing at an alarming rate especially in Western societies. Because of this, it is important to understand the regulating mechanisms involved in...
View ArticleTumors Induced in Mice by Direct Inoculation of Plasmid DNA Expressing Both...
Vaccines contain residual DNA derived from the cells used to produce them. As part of our investigation to assess the risk of this cellular DNA, we are developing a quantitative in vivo assay to...
View ArticleThe ulcerative colitis marker protein WAFL interacts with accessory proteins...
Ulcerative colitis (UC) is one of the major forms of inflammatory bowel disease with unknown cause. A molecular marker, WAFL, has recently been found to be up-regulated in the inflamed colonic mucosa...
View ArticleThe complete mitochondrial genome of the fall webworm, Hyphantria cunea...
The complete mitochondrial genome (mitogenome) of the fall webworm, Hyphantria cunea (Lepidoptera: Arctiidae) was determined. The genome is a circular molecule 15 481 bp long. It presents a typical...
View ArticleStudies on the Developmental Potentiality of Cultured Cell Nuclei of Fish
By means of the serial nuclear transplantation technique, the authors obtained a nuclear transplant fish from subcultured cell originated from the blastula cells of the crucian carp (Carassius auratus...
View ArticleUncoupling oxidative/energy metabolism with low sub chronic doses of...
A variety of evidence suggests that the failure of cellular metabolism is one of the underlying causes of neurodegenerative diseases. For example, the inhibition of mitochondrial function produces a...
View ArticleAnalysis of differentially expressed mitochondrial proteins in chromophobe...
Renal oncocytomas (RO) and chromophobe renal cell carcinomas (RCC) display morphological and functional alterations of the mitochondria. Previous studies showed that accumulation of mitochondria in...
View ArticleLeukocyte infiltration as a surrogate marker for diagnosis of invasion
Dr. YG Man's hypothesis that breast tumor invasion is triggered by the aberrant leukocyte infiltration induced by degeneration of myoepithelial cells holds a lot of truth in our clinical practice, and...
View Article
