Natural and artificial mutants as valuable resources for functional genomics...
With the completion of rice genome sequencing, large collection of expression data and the great efforts in annotating rice genomes, the next challenge is to systematically assign functions to all...
View ArticleNIP/DuoxA is essential for Drosophila embryonic development and regulates...
NIP/DuoxA, originally cloned as a protein capable of binding to the cell fate determinant Numb in Drosophila, was recently identified as a modulator of reactive oxygen species (ROS) production in...
View ArticleNotch and Wnt Signaling, Physiological Stimuli and Postnatal Myogenesis
Adult skeletal muscle stem cells, termed satellite cells are imperative to muscle regeneration. Much work has been performed on satellite cell identification and the subsequent activation of the...
View ArticleMelatonin Plays a Protective Role in Postburn Rodent Gut Pathophysiology
Melatonin is a possible protective agent in postburn gut pathophysiological dynamics. We investigated the role of endogenously-produced versus exogenously-administered melatonin in a major thermal...
View ArticleAntiviral actions of flavanoid-derived compounds on dengue virus type-2
Dengue viruses, mosquito-borne members of the Flaviviridae family, are the causative agents of dengue fever and its associated complications, dengue haemorrhagic fever and dengue shock syndrome. To...
View ArticleSurvival of Escherichia coli under lethal heat stress by L-form conversion
Transition of bacteria to cell wall deficient L-forms in response to stress factors has been assumed as a potential mechanism for survival of microbes under unfavorable conditions. In this article, we...
View ArticleCloning, characterization, and expression analysis of goat (Capra hircus)...
Phospholipid hydroperoxide glutathione peroxidase (PHGPx), as a ubiquitous antioxidant enzyme in the glutathione peroxidases (GPx) family, plays multiple roles in organisms. However, there is very...
View ArticleGeneration of Fgfr3 Conditional Knockout Mice
Fibroblast growth factor receptor 3 (FGFR3), highly conserved in both humans and murine, is one of key tyrosine kinase receptors for FGF. FGFR3 is expressed in different tissues, including cartilage,...
View ArticleWater Buffalo Genome Science Comes of Age
The water buffalo is vital to the lives of small farmers and to the economy of many countries worldwide. Not only are they draught animals, but they are also a source of meat, horns, skin and...
View ArticleDifferential transcriptional analysis between red and white skeletal muscle...
In order to better understand and elucidate the major determinants of red and white muscle phenotypic properties, the global gene expression profiling was performed in white (longissimus doris) and...
View ArticleRegulation of Vid-dependent degradation of FBPase by TCO89, a component of...
A pivotal gluconeogenic enzyme in Saccharomyces cerevisuae, fructose-1, 6-bisphosphatase (FBPase) was selectively turned over in vacuole via Vid (vacuole import and degradation) dependent pathway in...
View ArticleProliferation of Myoblast Skeletal Cells on Three-Dimensional...
Cardiac and skeletal muscle tissue engineering provides a smart approach to overcome problems associated with organ transplantation and cardiac tissue and also lays a platform for superior alternative...
View ArticleE2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity
E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation. Interaction between pRB and E2F-1 is dependent on the phosphorylation status of pRB. Despite the fact that...
View ArticleSustained Expression of TDP-43 and FUS in Motor Neurons in Rodent's Lifetime
TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) are two highly conserved ribonucleoproteins. Pathogenic mutations of the TDP-43 or the FUS gene are all linked to amyotrophic lateral...
View ArticleSubtle evolutionary changes in the distribution of N-glycosylation sequons in...
Many viruses are known to undergo rapid evolutionary changes under selective pressures. The HIV-1 envelope glycoprotein 120 (gp120) shows extreme selection for NXS/T sequons, the potential sites of...
View ArticleFluorouracil Selectively Enriches Stem-like Leukemic Cells in a Leukemic Cell...
Recent studies have reported that cancer stem cells (CSCs) could be isolated from solid cancer cell lines, in which the purity of CSCs was higher than that from tumor tissues. Separation of CSCs from...
View ArticleIncreased invasiveness and aggressiveness in breast epithelia with...
Our previous studies revealed that pregnancy associated breast cancer (PABC) had significantly reduced nuclear p63 expression in myoepithelia, while intense cytoplasmic p63 expression in associated...
View ArticleCatalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the...
To investigate the role and mechanism of catalpol in brain angiogenesis in a rat model of stroke, the effect of catalpol (5 mg/kg; i.p) or vehicle administered 24 hours after permanent middle cerebral...
View ArticleExpression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors
Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline. The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study...
View ArticleSkeletal Muscle Stem Cells from Animals I. Basic Cell Biology
Skeletal muscle stem cells from food-producing animals are of interest to agricultural life scientists seeking to develop a better understanding of the molecular regulation of lean tissue (skeletal...
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